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Reproduction studies in animals (mice and rats) with orally and parenterally administered amoxicillin/clavulanate have shown no teratogenic effects. There is limited experience in human pregnancy. As with all medicines, use should be avoided in pregnancy, especially during the 1st trimester, unless considered essential by the physician.
Although significant problems in human have not been documented, caution should be exercised when amoxicillin/clavulanate is administered to nursing mothers, because, it may lead to sensitization, diarrhea, candidiasis and skin rash in the infant.
